| ncRNA name | hsa-miR-133b |
| ncRNA Category | miRNA |
| Disease name | age-related cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | anterior lens capsule; human lens epithelial cell line HLE-B3 |
| Methods | qRT-PCR, transfection, Western blot, luciferase reporter assay |
| Expression pattern | down-regulated |
| Functional description | BCL2L2 was the virtual target of miR-133b, and we found a negative regulatory relationship between miR-133b and BCL2L2. miR-133b positively interfered with the viability of cells, while BCL2L2 negatively interfered with the viability of cells, and that miR-133b inhibited apoptosis while BCL2L2 accelerated apoptosis. |
| PubMed ID | 27802259 |
| Year | 2016 |
| Title | Down-Regulation of MicroRNA-133b Suppresses Apoptosis of Lens Epithelial Cell by Up-Regulating BCL2L2 in Age-Related Cataracts. |
| Drug-related ncRNA | NO |
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